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What is a superantigen?

a) An extremely potent antibiotic
b) A type of viral antigen
c) A class of highly immunogenic toxins
d) A specific T cell receptor

User AbdelAli
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1 Answer

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Final answer:

A superantigen is a class of toxins that cause an uncontrolled activation of T cells leading to a dangerous systemic inflammatory response, often resulting in life-threatening conditions.

Step-by-step explanation:

A superantigen is a class of potent toxins produced by some bacterial and viral pathogens. They lead to a highly immunogenic response by causing an unregulated, nonspecific activation of T cells, which results in a massive cytokine release known as a cytokine storm. This can cause severe immune reactions, including potentially life-threatening conditions such as toxic shock syndrome, fevers, low blood pressure, multi-organ failure, and shock.

The mechanism of action for superantigens involves the binding to Major Histocompatibility Complex (MHC) II molecules on antigen-presenting cells and the variable region of the T cell receptor (TCR) ß chain, without the need for specific foreign epitope recognition. This inappropriate activation can have dire consequences due to the overwhelming inflammatory response it induces.

User Patrick Burns
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