Final answer:
The 1330s marked the beginning of the plague's appearance in Eastern Europe, Western Europe, Central Asia, and the Middle East. The disease originated in Central Asia and then spread to China, Europe, and other regions through trade routes such as the Silk Roads. The plague had a devastating impact on these regions.
Step-by-step explanation:
The 1330s marked the beginning of the plague's appearance in Eastern Europe, Western Europe, Central Asia, and the Middle East. The disease originated in Central Asia and then spread to China, Europe, and other regions through trade routes such as the Silk Roads. The plague had a devastating impact on these regions, resulting in massive mortality rates and social and economic disruptions.