Final answer:
William Henry Harrison achieved victory over the Second Native Confederacy at the Battle of the Thames in 1813, where Tecumseh was killed, undermining the confederation. Previously, Harrison also won the Battle of Tippecanoe in 1811.
Step-by-step explanation:
William Henry Harrison claimed victory over a part of the Second Native Confederacy at the Battle of the Thames in 1813, which was a decisive encounter during the War of 1812. The battle resulted in the death of Tecumseh, who had been a pivotal leader in bringing the Indian tribes together against American expansion. Earlier, in 1811, Harrison also led U.S. forces to victory at the Battle of Tippecanoe, which was significant not for the military win itself, but rather for the subsequent dismantling of the native alliance that had been centered around Prophetstown.