Final answer:
To change 'Hello, world' to 'Yello, world', use the method greeting.replace('H', 'Y') since strings are generally immutable and cannot be altered by index.
Step-by-step explanation:
To change the first letter of the string variable greeting with the value "Hello, world" to 'Y' to produce the output "Yello, world", you should use option B: greeting.replace('H', 'Y'). This is because strings in many programming languages are immutable, which means they cannot be changed after they are created. So, you cannot directly change a character at a specific index like in option A. Using the replace method creates a new string with the specified changes.
Options A and C are incorrect because you typically cannot assign a value to a string index. Option D, swapcase(), is incorrect because it would invert the case of all the letters in the string, not change 'H' to 'Y'.