Question

In the citric acid cycle's impact on glycolysis, which statement accurately describes the mechanism?

a) Citrate inhibits glycolysis enzymes.
b) Citrate activates glycolysis enzymes.
c) Citrate serves as a substrate in glycolysis.
d) Citrate regulates glycolysis gene expression.

Answer 1

Citrate serves as a substrate in glycolysis in the citric acid cycle. High levels of ATP or citrate and lower pH can decrease the activity of glycolysis enzymes.

Step-by-step explanation:

In the citric acid cycle, citrate serves as a substrate in glycolysis. When citrate is produced in the citric acid cycle, it can be converted back into oxaloacetate and then enter glycolysis to generate more ATP. This helps to maintain the flow of energy production in the cell.

Factors such as high levels of ATP or citrate and a lower pH can decrease the activity of glycolysis enzymes, including phosphofructokinase and pyruvate kinase. These enzymes are key regulators of glycolysis and are important for controlling the rate of ATP production.