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Which sterilization method is suitable for the following packaging materials: polyolefin wraps and Tyvek (all-plastic) pouches that have been validated for use with low-temperature hydrogen peroxide

a) Radiation sterilization
b) Dry heat sterilization
c) Ethylene oxide
d) Steam sterilization

1 Answer

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Final answer:

Ethylene oxide sterilization (c) is the suitable method for sterilizing polyolefin wraps and Tyvek pouches validated for low-temperature hydrogen peroxide use, due to its ability to sterilize at low temperatures without damaging heat-sensitive materials.

Step-by-step explanation:

For the sterilization of packaging materials such as polyolefin wraps and Tyvek pouches validated for use with low-temperature hydrogen peroxide sterilization, ethylene oxide (c) is the most suitable method. Ethylene oxide is a gas sterilant that can permeate heat-sensitive packaged materials. It is highly penetrating and operates at low temperatures, which is ideal for materials that cannot withstand heat, such as the specific packaging materials mentioned. Its properties make it a preferred choice for sterilizing complex medical devices and equipment. However, due to its carcinogenic and explosive nature, it should be handled with great care.

Though radiation sterilization (a), such as gamma irradiation, is effective at sterilizing heat-sensitive materials, its use is more appropriate when items are already packaged and when specific validation for the mentioned packaging materials under radiation has not been established. Dry heat (b) and steam sterilization (d) are less suitable for these types of materials as they require higher temperatures that can compromise their structural integrity.

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