Final answer:
Opioid effects that do not exhibit tolerance in opioid therapy are constipation and miosis.
Step-by-step explanation:
Opioid effects that do not exhibit tolerance include constipation and miosis.
Constipation is a common side effect of opioids because they slow down the movement of the gastrointestinal tract. This effect does not develop tolerance over time, meaning that it remains constant even with long-term opioid use.
Miosis refers to excessive constriction of the pupil. Opioids cause this effect by stimulating the parasympathetic nervous system, and it also does not develop tolerance.
The implications of these effects in opioid therapy include the need for patients to manage constipation through dietary changes and the use of laxatives. Additionally, healthcare providers need to be aware of the potential for miosis as a side effect and consider it when assessing patients on opioids.