Final answer:
The pulmonary artery is the large artery that carries de-oxygenated blood from the heart to the lungs.
Step-by-step explanation:
The artery that is a prominent, large artery carrying de-oxygenated blood is the pulmonary artery. This is an exception to the general rule that arteries carry oxygenated blood. The pulmonary artery is unique as it transports deoxygenated blood from the right ventricle of the heart to the lungs for oxygenation. In the lungs, gas exchange occurs where blood becomes oxygenated before returning to the heart via the pulmonary veins.