Final answer:
The oral medication with the MOST potential to cause a serious interaction with Amiodarone is Warfarin (Coumadin).
Step-by-step explanation:
The oral medication with the MOST potential to cause a serious interaction with Amiodarone is Warfarin (Coumadin). Warfarin is an anticoagulant medication used to prevent blood clots. When combined with Amiodarone, which is an antiarrhythmic medication, it can increase the risk of bleeding.