Final answer:
The greatest risk factor for the 70-year-old man with severe left thigh pain and Clostridium septicum infection is the presence of underlying disease.
Step-by-step explanation:
The greatest risk factor for the 70-year-old man with severe left thigh pain and Clostridium septicum infection is the presence of underlying disease. The article states that patients with underlying disease have a high fatality rate of about 50%. Individuals with chronic liver disease or who are immunodeficient are particularly at risk for developing a severe infection.