Final answer:
Fats Domino's commercial success was driven by his ability to appeal to a broad audience with his infectious rhythm and blues-infused rock and roll hits.
Step-by-step explanation:
Fats Domino's commercial success was driven by his ability to appeal to a broad audience with his infectious rhythm and blues-infused rock and roll hits. His music resonated with teenagers across the country and became hugely popular, making him one of the first rock and roll stars to achieve significant commercial success. Domino's songs, such as "Blueberry Hill" and "Ain't That a Shame," were catchy and had a universal appeal that helped him gain popularity.