Question

Which pt will LEAST likely have pronounced up regulation of nicotinic AchE Receptors

a. 31 yo with acute severe spinal cord injury 10 hours ago
b. Female intubated in ICU for 18 days
c. female undergoing skin grafting for 3rd degree burns 1 week prior
d. female with long term MS

Answer 1

The patient who is LEAST likely to have pronounced upregulation of nicotinic AchE receptors is a female with long-term MS.

Step-by-step explanation:

The patient who is LEAST likely to have pronounced upregulation of nicotinic AchE receptors is d. a female with long-term MS.

Upregulation of nicotinic AchE receptors occurs in response to decreased acetylcholine (ACh) activity, in order to compensate for reduced neurotransmitter availability. Therefore, conditions that result in decreased ACh release or impaired ACh function would be more likely to lead to upregulation of these receptors. In this case, acute severe spinal cord injury, prolonged intubation, and the recent skin grafting procedure are all conditions that could lead to decreased ACh activity, whereas long-term MS does not directly affect ACh release or function.