Final answer:
Glycine is the irrigation solution used in TURP associated with Acute Kidney Injury. It can lead to TURP syndrome if absorbed in large quantities, while isotonic solutions like normal saline and Ringer's lactate are less likely to cause severe complications like AKI. Understanding the role of isotonic solutions and the function of oliguric drugs in managing fluid balance and hypotension is important in medicine.
Step-by-step explanation:
The irrigation solution used in Transurethral Resection of the Prostate (TURP) associated with Acute Kidney Injury (AKI) is glycine. During the TURP procedure, irrigation solutions are used to clear the surgical area, but if absorbed into the bloodstream in large quantities, certain solutions can cause complications. Glycine is a non-electrolytic and hypo-osmolar solution, which, if absorbed, can lead to the TURP syndrome. This syndrome can cause various symptoms, including AKI, due to the rapid shift of fluids and the effects of the excess glycine on the kidneys. In comparison, normal saline and Ringer’s lactate are isotonic solutions that are less likely to be associated with severe complications such as AKI following their absorption during the TURP procedure.
It is important that irrigation solutions like normal saline and lactated Ringer's solution are isotonic because isotonic solutions have the same osmotic pressure as the body's fluids, preventing the risk of significant fluid shifts within the body that might occur with hypo- or hypertonic solutions. These shifts can disrupt cellular function and potentially lead to serious complications.
The use of an oliguric drug, as noted in the reference, suggests a medication that works by influencing kidney function, specifically affecting the loop of Henle to inhibit the reabsorption of sodium (Na+) and chloride (Cl–) ions, which can be crucial in managing conditions like hypotension. However, this does not directly relate to the choice of irrigation solution in TURP, but rather it is important information in the context of kidney function and fluid balance in the human body.