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AIDS and progressive hemiparesis and R homonymous visual field deficit assoc w patchy white matter lesions on MRI with normal routine CSF.

User Kasakka
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Final answer:

The student is inquiring about a medical situation involving progressive hemiparesis and visual field deficits, which may correspond to a neurological condition such as Creutzfeldt-Jakob disease or an infection impacting the nervous system, potentially requiring multiple clinical tests for diagnosis.

Step-by-step explanation:

The student's question is related to a complex medical situation involving progressive hemiparesis and a right homonymous visual field deficit, the latter of which might suggest an optic chiasm defect potentially due to a pituitary gland issue. However, the presence of patchy white matter lesions on an MRI and normal routine cerebrospinal fluid (CSF) findings add another layer of complexity. In one case study, similar CSF findings, including the absence of expected signs such as infection, but with high concentrations of 14-3-3 protein, suggested a diagnosis of Creutzfeldt-Jakob disease (CJD), a neurodegenerative condition. Additionally, the visual field deficits appear not to originate within the visual system itself but due to compression from another structure, such as a pituitary gland growth.

Since the symptoms include a stiff neck and progressive hemiparesis, and considering the complex case study where a spinal tap indicated a cerebrospinal infection, the patient’s physician may suspect a neurological infection spreading, such as meningitis. In this context, differential diagnosis might include conditions such as neurosyphilis or meningitis, where multiple tests, including VDRL-CSF, might be employed to rule out these conditions. Furthermore, given the loss of peripheral vision known as bilateral hemianopia, neuroimaging and visual field assessments are critical in determining the impact on the optic pathways.

User Alexander Solovets
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