Final answer:
The antidepressant that has active metabolites that extend its effective half-life is mirtazapine (Remeron). Mirtazapine is an atypical antidepressant that works by blocking specific serotonin and norepinephrine receptors.
Step-by-step explanation:
The antidepressant that has active metabolites that extend its effective half-life is mirtazapine (Remeron). Mirtazapine is an atypical antidepressant that works by blocking specific serotonin and norepinephrine receptors. It is metabolized into several active compounds, including its main metabolite, desmethylmirtazapine, which has a half-life of approximately 20-40 hours.
Unlike other antidepressants that are quickly eliminated from the body, the active metabolites of mirtazapine contribute to its prolonged duration of action. This extended half-life allows for a once-daily dosing regimen, which can be convenient for patients.