Final answer:
The optimal strategy in maintenance treatment with tricyclics for patients with recurrent MDD involves continued long-term use of these antidepressants to prevent relapse of symptoms. Tricyclics may initially cause unpleasant feelings when given to normal individuals, but can lead to an elevated mood over time when administered to depressed patients. These medications are not prescribed on an as-needed basis, but rather for maintenance treatment.
Step-by-step explanation:
The optimal strategy for maintenance treatment with tricyclics for patients with recurrent major depressive disorder (MDD) involves continued use of these antidepressants over an extended period of time. Tricyclic antidepressants, such as imipramine and amitriptyline, are prescribed on a long-term basis to prevent relapse of MDD symptoms.
Unlike the monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants do not have a stimulating or mood-elevating effect when given to normal individuals; instead, they may cause sleepiness, reduced blood pressure, light-headedness, and unpleasant feelings of unhappiness and increased anxiety. However, over time, when administered to depressed patients, tricyclics can lead to an elevated mood.
It's important to note that tricyclic antidepressants are not typically prescribed as-needed but are used for maintenance treatment of MDD symptoms. This approach aims to prevent relapse and sustain the therapeutic effects of the medication.