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A pt w/ treatment-resistant mania and h/o rapid cycling is being treated w/ carbamazepine and thyroxine. After adding Clozapine the pt is clinically stabilized. The pt's most recent WBC is below 3,000. Intervention?

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Final answer:

When a patient on Clozapine presents with a WBC count below 3000, medical intervention is required. This may include pausing or adjusting medication due to the risk of agranulocytosis, paralleling chemotherapy considerations for low ANC.

Step-by-step explanation:

A patient with treatment-resistant mania and a history of rapid cycling is being treated with carbamazepine and thyroxine. After adding Clozapine the patient is clinically stabilized. However, the patient's most recent white blood cell (WBC) count is below 3,000, which indicates leukopenia, a condition where the WBC count is low. In such cases, the intervention typically requires close monitoring and possible adjustment of medications, especially like Clozapine, which is known to cause agranulocytosis as a side effect. Immediate contact with the healthcare provider is necessary to discuss the potential risks and a plan of action that can include a pause in medication, dosage adjustment, or alternative therapies. The scenario parallels the common chemotherapy side effect of leukocyte destruction and would generally prompt a reassessment of treatment due to the risk of infection associated with low neutrophil counts as indicated by the absolute neutrophil count (ANC).

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