Final answer:
The risk of hepatotoxicity after an acetaminophen overdose typically peaks within 24 to 72 hours. It is important to monitor for signs of overdose and seek medical attention early. The ALT enzyme level rise is a critical marker for liver damage after overdose.
Step-by-step explanation:
The risk of hepatotoxicity after an acetaminophen overdose typically peaks within 24 to 72 hours following ingestion. Acetaminophen metabolites can cause liver damage, which is indicated by a dramatic rise in alanine aminotransferase (ALT) levels in the blood. Symptoms of an overdose may not be immediate and can include a latent period of 4-8 hours, which can make it challenging to recognize the severity of the overdose. Therefore, it is crucial to seek medical attention immediately if an overdose is suspected, as early intervention can be key in preventing serious liver damage or failure.