Final answer:
Consult with a healthcare professional to explore other treatment options for a 45-year-old with MDD that has not responded well to Paxil and therapy.
Step-by-step explanation:
The best intervention for a 45-year-old with first episode Major Depressive Disorder (MDD) who has not responded well to Paxil and insight-oriented therapy is to consult with a healthcare professional to discuss other treatment options. It is important to address the concerns about becoming dependent on medication, but there are alternative antidepressants that can be considered. Additionally, other treatment modalities such as psychotherapy, electroconvulsive therapy, or deep-brain stimulation may be explored.