Final Answer:
Fluoxetine (Prozac) is the SSRI antidepressant with the longest mean half-life, which is approximately 2 to 4 days.
Step-by-step explanation:
Fluoxetine (Prozac), among the selective serotonin reuptake inhibitor (SSRI) antidepressants, stands out with the longest mean half-life, ranging from 2 to 4 days. The extended half-life is attributed to its active metabolite, norfluoxetine, which also contributes to its sustained therapeutic effects.
The prolonged duration of action allows for a more gradual onset and offset of therapeutic effects, making fluoxetine a unique choice in the SSRI class. This characteristic can be advantageous for patients who may benefit from a less frequent dosing schedule or those who are more prone to missing doses.
However, it's essential to consider individual patient characteristics and treatment goals when selecting an antidepressant, as the pharmacokinetic profile, side effects, and response to treatment vary among individuals.