Final answer:
Monoamine Oxidase Inhibitors (MAOIs) are antidepressants that have been known to induce hypertension. While effective for depression, their use is limited due to significant side effects. Today, SSRIs and tricyclic antidepressants are more commonly prescribed and have fewer side effects.
Step-by-step explanation:
The antidepressant known to have induced hypertension is the class of drugs called Monoamine Oxidase Inhibitors (MAOIs). These were one of the first effective antidepressants and have the ability to block oxidative deamination of monoamines, which increases levels of neurotransmitters like dopamine, serotonin, and norepinephrine. Although effective, MAOIs have numerous side effects, including the risk of causing high blood pressure (hypertension).
While MAOIs were once used to treat hypertension, this was discontinued due to their side effects and the availability of better-tolerated blood pressure medications. Now, the use of MAOIs for depression is somewhat limited and is often only considered when other drugs such as tricyclic antidepressants provide unsatisfactory results or in certain cases of neurotic illnesses accompanied by anxiety and phobias that respond favorably to them.
Other classes of antidepressants like Selective Serotonin Reuptake Inhibitors (SSRIs) and tricyclic antidepressants are now more commonly used and have a different side effect profile, including generally having fewer anticholinergic side effects than MAOIs.