Question

First-degree relatives of patient with BMD II have a higher incidence of what disorder?

Answer 1

First-degree relatives of patients with Bipolar Mood Disorder II are at an increased risk of familial hypercholesterolemia, a condition characterized by high LDL cholesterol levels and associated with genetic mutations in the LDL receptor and ApoB genes.

Step-by-step explanation:

First-Degree Relatives of Patients with BMD II

First-degree relatives of patients with Bipolar Mood Disorder II (BMD II) are at an increased risk of familial hypercholesterolemia. Familial hypercholesterolemia is a genetic condition primarily caused by mutations in two genes: the LDL receptor gene on chromosome 19 and the ApoB gene. This condition is characterized by high levels of low-density lipoprotein (LDL) cholesterol in the blood, which can lead to tendon xanthoma, xanthelasma, and premature cardiovascular disease. It can be familial due to these genetic mutations or can occur from dietary factors, known as polygenic hypercholesterolemia.

The significance of lipid disorders such as familial hypercholesterolemia in first-degree relatives of patients with BMD II is notable because these conditions can contribute to overall health risks. Furthermore, understanding the genetic predisposition to such conditions can aid in early identification and management strategies, thereby potentially reducing their impact on morbidity and mortality in these families.