Final answer:
Folic acid supplements can be taken with methotrexate to help with adverse effects.
Step-by-step explanation:
Methotrexate is a medication used to treat various conditions, including cancer and autoimmune diseases. However, it can have some adverse effects. One way to help mitigate these adverse effects is by taking folic acid supplements. Methotrexate inhibits folic acid reductase, which is responsible for the conversion of folic acid to tetrahydrofolic acid. By taking folic acid supplements, it can help provide the body with the necessary coenzymes needed for certain reactions.