Final answer:
The nurse should respect the family's decision, provide education and support, and collaborate with the healthcare team to develop a palliative care plan for comfort and support of the infant.
Step-by-step explanation:
When a family decides to refuse transfer to intensive care for an infant and instead institute comfort measures, the nurse should first respect the family's decision. It's important to provide support and education to the family about the care plan and ensure that they fully understand the implications of their choice. Following this, the nurse should collaborate with the healthcare team to develop and implement a palliative care plan focused on comfort and support for the infant. Clear communication and compassionate support are key components in caring for the family and the infant during this difficult time.