Final answer:
The first-line antibiotic for otitis media is high-dose amoxicillin, but other antibiotics may also be used. Vaccination can help decrease the risk of otitis media.
Step-by-step explanation:
The first-line antibiotic for otitis media is high-dose amoxicillin. However, with increasing resistance concerns, macrolides and cephalosporins may also be used. The pneumococcal conjugate vaccine (PCV13) and influenza vaccine have been shown to decrease the risk for otitis media.