Question

Myasthenia gravis is an autoimmune disease that slowly destroys receptors at the motor end plate. Which types of receptors are destroyed?

Answer 1

Myasthenia gravis is an autoimmune disease that targets and destroys nicotinic acetylcholine receptors on muscle cells at the neuromuscular junction, leading to muscle weakness and fatigue.

Step-by-step explanation:

Myasthenia gravis is an autoimmune disease characterized by the production of autoantibodies that attack the body's own acetylcholine receptors at the neuromuscular junction motor endplate. These receptors normally bind acetylcholine, a neurotransmitter essential for the initiation of muscle contraction. In myasthenia gravis, the impaired function of these receptors leads to muscle weakness and fatigue. This disorder is known for weakening muscles over time and can significantly impair motor functions, including those necessary for breathing, swallowing, and eye movement.The receptors destroyed are the nicotinic acetylcholine receptors found on the muscle cells at the neuromuscular junction. Upon normal activation by acetylcholine, these receptors lead to muscle contraction. The attack by autoantibodies results in fewer functional receptors, decreased muscle stimulation, and muscle weakness—a hallmark feature of myasthenia gravis.