Final answer:
It is false that neurologic manifestations always precede cardiac symptoms in LAST; symptoms may vary, and cardiac symptoms can sometimes occur first or without preceding neurologic signs.
Step-by-step explanation:
The statement that neurologic manifestations are always seen before cardiac symptoms develop in LAST (Local Anesthetic Systemic Toxicity) is false. While it is common for neurologic symptoms to appear first, given the high sensitivity of the CNS to local anesthetics, there is no fixed sequence for the presentation of symptoms, and cardiac symptoms can sometimes precede or occur without preceding neurological signs.
Local Anesthetic Systemic Toxicity is a rare but potentially life-threatening condition caused by the systemic absorption of local anesthetics, which can affect both the nervous and cardiovascular systems. The onset of symptoms is often sudden, with neurological signs possibly including altered mental status, seizures, and sensory disturbances, while cardiac manifestations might include arrhythmias, hypotension, and potentially cardiac arrest.