Final answer:
Cold is not a cardinal sign of inflammation; instead, the cardinal signs are redness, swelling, pain, and local heat, along with possible loss of function.
Step-by-step explanation:
Among the options provided, C. cold is NOT a cardinal sign of inflammation. The four cardinal signs of inflammation as first documented by Cornelius Celsus, are redness, swelling (edema), pain, and local heat. A fifth sign, loss of function, may also accompany these signs. Fever, which is not listed here, is a systemic sign and not a local sign of inflammation. Inflammation leads to these symptoms due to processes such as increased blood flow and vascular permeability which bring immune cells and fluid to the site of injury or infection.