Final answer:
The discovery of human remains in a Portuguese cave in 1999 is significant as it indicates the interbreeding between Neanderthals and modern humans, with genetic evidence showing a small percentage of Neanderthal DNA in modern populations.
Step-by-step explanation:
The analysis of human remains found in a Portuguese cave in 1999 is intriguing because it supports the idea that there was interbreeding between Neanderthals and modern humans, Homo sapiens. This is evidenced by studies indicating that modern European and Middle Eastern populations have between 1 and 4 percent Neanderthal DNA. Additionally, the discovery of a first-generation hybrid individual with a Denisovan father and a Neanderthal mother, known as Denny, provides further evidence of interactions between different Homo species in the Late Pleistocene when these groups met.
Modern DNA analysis has confirmed mating between Neanderthals and modern humans, suggesting that the Neanderthal population may have been assimilated rather than going extinct. This theory is further supported by genetic evidence from Denisovans, who also interbred with Neanderthals and modern humans, leaving a lasting impact on human genetics.