Final answer:
The earliest known blues musicians originated from the Mississippi Delta, which is recognized as the birthplace of blues music.
Step-by-step explanation:
The earliest known blues musicians came from the Mississippi Delta. This region is often regarded as the birthplace of blues music, which evolved from spirituals and work songs created by African Americans in the South. The style was characterized by its expressive 'blue' notes and unique chord progressions, reflecting the highs and lows of life. Frequently associated with African-American experiences, the blues laid a foundation for genres like jazz and rock 'n' roll. Famous for its rich musical heritage, the Delta produced legendary blues artists who inspired countless musicians and the evolution of American music.