Final answer:
Left ventricular enlargement is a two dimensional echocardiographic finding that may indicate significant chronic mitral regurgitation.
Step-by-step explanation:
A two dimensional echocardiographic finding that may indicate significant chronic mitral regurgitation is left ventricular enlargement. Mitral regurgitation refers to the backflow of blood from the left ventricle into the left atrium due to a faulty mitral valve. Over time, this extra volume of blood can cause the left ventricle to enlarge as it tries to compensate for the regurgitation.