Final answer:
A malignant complication of being on chronic immunosuppressive therapy is the increased risk of developing cancer. Patients on long-term immunosuppressive therapy have an increased risk of developing skin cancers such as Kaposi's sarcoma, and HIV patients on immunosuppressive therapy are at increased risk of lymphomas.
Step-by-step explanation:
A malignant complication of being on chronic immunosuppressive therapy is the increased risk of developing cancer. Immunosuppressive therapy weakens the immune system, making it less able to detect and destroy abnormal cells that can develop into cancer. For example, patients on long-term immunosuppressive therapy after organ transplantation have an increased risk of developing skin cancers such as Kaposi's sarcoma.
Another example is the increased risk of lymphomas in patients with HIV infection who are on immunosuppressive therapy. HIV compromises the immune system and when combined with immunosuppressive therapy, it further increases the risk of malignancies.
It is important for patients on chronic immunosuppressive therapy to undergo regular cancer screenings and to be aware of the signs and symptoms of cancer so that early detection and treatment can be possible.