Final answer:
After the S phase, a human cell has 46 pairs of sister chromatids and 92 individual DNA molecules, with sister chromatids attached by centromeres.
Step-by-step explanation:
Following the S phase of interphase in a human cell, each of the 46 chromosomes has been replicated into two copies known as sister chromatids, resulting in a total of 92 chromatids. These chromatids are held together at a specialized region called the centromere. The cell would thus have 46 pairs of sister chromatids and 92 individual DNA molecules in preparation for the subsequent phases of cell division. It's important not to confuse sister chromatids with homologous chromosome pairs, which consist of similar but not identical chromosomes coming from each parent.
Therefore, after the S phase, a human cell would have 46 pairs of sister chromatids, as there are 46 chromosomes in a human cell.
Each pair of sister chromatids represents an individual DNA molecule, so after the S phase, a human cell would have 92 individual DNA molecules.