Question

Low-carbohydrate diets became popular in the late 1990s and were quickly proclaimed to be a fast and easy method of weight loss. The effectiveness and safety of these diets are dependent on the activity and overall health of the individual as well as the total nutritional content of the diet. However, it is true that in some cases, these diets have been effective. What metabolic effects caused by eating a low-carbohydrate diet can be linked directly to a decrease in fatty acid synthesis and an increase in fatty acid oxidation?

a. release of insulin from pancreatic's cells
b. dephosphorylation of AMPK
c. release of glucagon from pancreatic's cells
d. phosphorylation of AMPK

Answer 1

c. release of glucagon from pancreatic's cells

d. phosphorylation of AMPK

Step-by-step explanation:

Low-carbohydrate diets (LCDs) stimulate the secretion of glucagon by a decrease in the blood glucose concentration. Glucagon is a key hormone secreted by pancreatic cells in the same way as insulin but in an opposite way. This hormone (glucagon) prevents glucose accumulation as hepatic glycogen, while insulin helps to the accumulation of glucose in the liver as glycogen, thereby acting to reduce hepatic glucose output. Moreover, the AMP-activated protein kinase (AMPK) is a kinase protein that mediates the phosphorylation and inhibition of acetyl-CoA carboxylase (ACC) in order to reduce the synthesis of malonyl-CoA, a key molecule that regulates myocardial fatty acid oxidation.