Final answer:
Negative symptoms of schizophrenia worsen with increasing age.
Step-by-step explanation:
The most true statement regarding negative symptoms of schizophrenia is that they worsen with increasing age (option 4). Negative symptoms refer to a reduction or absence of normal functions, such as a flattened emotional state, loss of pleasure, and loss of basic drives. As individuals with schizophrenia age, these symptoms tend to worsen rather than improve. It is important to note that treatments for schizophrenia usually involve antipsychotic medications, not electroconvulsive therapy (ECT) or cognitive-behavioral therapy (CBT).