Final answer:
Smoking acts upon the pleasure pathways of the brain by increasing the release of dopamine.
Step-by-step explanation:
The statement that is true about smoking is that it acts upon the pleasure pathways of the brain. Nicotine, the active chemical constituent in tobacco, activates the reward system by increasing the release of dopamine, a neurotransmitter associated with pleasure and reward. This creates a pleasurable sensation, which can contribute to smoking addiction.