Prozac (fluoxetine), a Selective Serotonin Reuptake Inhibitor (SSRI), has the best evidence base for treating bulimia nervosa and is considered a first-line therapy for this condition due to its effectiveness and safety profile.
The drug with the best evidence base for use in bulimia nervosa is Prozac (fluoxetine), which is a type of Selective Serotonin Reuptake Inhibitor (SSRI). SSRIs like fluoxetine have been shown to be effective in treating the symptoms of bulimia nervosa. They operate by blocking the reuptake of serotonin in the brain, which helps in reducing the binge-purge cycles and improving mood. Unlike tricyclic antidepressants (TCAs), SSRIs generally have fewer anticholinergic side effects. Fluoxetine, in particular, has been approved by the FDA for the treatment of bulimia nervosa, making it a first-line therapy for this condition.