Question

When do helper T-cells develop into TH1 or TH₂ cells?

1) Before autostimulation
2) Immediately after the binding of the CD4 receptor
3) After proliferation into a clonal population
4) After B cell activation

Answer 1

Helper T-cells develop into TH1 or TH2 cells after proliferation into a clonal population, directed by cytokines secreted by APCs in response to pathogens. The correct option is 3) After proliferation into a clonal population

Step-by-step explanation:

Helper T-cells develop into TH1 or TH2 cells after they have proliferated into a clonal population. The differentiation into either TH1 or TH2 is influenced by cytokines secreted by cells of the innate immune system in response to the nature of the invading pathogen.

Specifically, this occurs after the activation of the helper T cells by antigen-presenting cells (APCs) and the subsequent proliferation and clonal expansion directed by APC-secreted cytokines.

Differentiation into various subtypes, including TH1, TH2, or memory helper T cells, takes place as part of the immune response where TH1 cells are associated with inflammation and intracellular pathogens, while TH2 cells are vital for stimulating B cells to secrete antibodies targeting extracellular pathogens. The correct option is 3) After proliferation into a clonal population