Final answer:
In the period from 1800 to 1860, the South experienced economic changes due to cotton production, but it did not produce a significant proportion of the nation's manufactured goods.
Step-by-step explanation:
In the period from 1800 to 1860, the South went through significant economic changes due to its reliance on cotton production. However, among the statements provided, the one that is NOT true is: 2) The South produced nearly two-fifths of the nation's manufactured goods, especially cotton textiles. While the South did produce a significant amount of cotton, it did not contribute as significantly to the nation's overall manufacturing sector.