Final answer:
A silent mutation, often a result of a substitution, is most likely to have no effect on the protein's amino acid sequence because it encodes the same or a chemically similar amino acid.
Step-by-step explanation:
The type of mutation most likely to have no effect on the amino acid chain formed is a silent mutation. This occurs when a point mutation or substitution, such as a change from CCA to CCU, results in the use of the same or a chemically similar amino acid (e.g., both codons encode proline). Unlike deletion, insertion, or monosomy, which often cause a frameshift or loss of genetic material and can lead to significant alterations in protein structure and function, silent mutations do not alter the amino acid sequence of the protein.