Final answer:
The primary first-line treatment for syphilis is penicillin G benzathine, with doxycycline, ceftriaxone, and azithromycin as alternatives for those allergic to penicillin. Retesting is important to confirm cure.
Step-by-step explanation:
First-line Treatment Options for Syphilis
The first-line treatment for syphilis includes antibiotics that are effective against the bacterium Treponema pallidum, which causes the disease. The most recommended treatment is penicillin G benzathine, which is usually administered through a single intramuscular injection and can cure primary, secondary, or early latent syphilis. For cases of late latent or tertiary syphilis, three weekly doses are generally required.
If an individual is allergic to penicillin, alternatives like doxycycline or other antibiotics such as ceftriaxone and azithromycin may be used, although they are generally considered less effective. Retesting for syphilis after treatment is crucial to ensure that the infection has been cleared.