Question

In thinking of the pathogenesis of peptic ulcer disease, what does H. Pylori cause?

1) Gastric acid hypersecretion
2) Decreased mucosal resistance
3) Impaired mucosal blood flow
4) All of the above

Answer 1

H. pylori causes peptic ulcers by colonizing the stomach cells, damaging the protective mucus barrier, and releasing toxins.

Step-by-step explanation:

H. pylori causes peptic ulcers by colonizing the epithelial cells in the stomach and producing urease, which neutralizes stomach acids. This damages the cells of the stomach lining, including those that produce the protective mucus barrier. Additionally, H. pylori can release toxins that induce vacuole formation in host cells and cause tissue damage. Therefore, the correct answer is All of the above.