Final answer:
The stratum corneum is the layer of the skin that has 3-5 layers of cells with shriveled nuclei. It is the most superficial layer of the epidermis and provides mechanical protection and prevents dehydration.
Step-by-step explanation:
The layer of the skin that has 3-5 layers of cells with shriveled nuclei is the Stratum Corneum. This is the most superficial layer of the epidermis and is exposed to the outside environment. It consists of dry, dead cells that provide mechanical protection against abrasion and prevent the penetration of microbes and dehydration of underlying tissues.