Question

Which is the most likely explanation for the defect in dystrophic epidermolysis bullosa, in which the skin blisters with any touch?

1) Deficiency of collagen
2) Deficiency of keratin
3) Deficiency of elastin
4) Deficiency of melanin

Answer 1

Dystrophic epidermolysis bullosa is most likely caused by a deficiency of collagen, specifically type VII collagen necessary for anchoring skin layers.

Step-by-step explanation:

The most likely explanation for the defect in dystrophic epidermolysis bullosa, in which the skin blisters with any touch, is a deficiency of collagen. Dystrophic epidermolysis bullosa is a condition that results from mutations affecting the collagen proteins, particularly type VII collagen, which is crucial for the anchoring of the epidermal layers to the underlying dermis. A deficiency in this collagen leads to the separation of these skin layers and the formation of blisters with minimal mechanical stress.