Final answer:
The layer of cells with visible large nuclei is the stratum granulosum. In this layer, the cells become flatter, their cell membranes thicken, and they generate large amounts of proteins such as keratin and keratohyalin.
Step-by-step explanation:
The layer of cells with visible large nuclei is the stratum granulosum. In this layer of the epidermis, the cells become flatter, their cell membranes thicken, and they generate large amounts of proteins such as keratin and keratohyalin. As the cells die, the nuclei and other cell organelles disintegrate, leaving behind the keratin, keratohyalin, and cell membranes.