Final answer:
The issue between Jorge and Ruth is a significant disagreement, likely related to the interpretation or sufficiency of evidence in a scientific or empirical context.
Step-by-step explanation:
The question at hand relates to what is at issue between Jorge and Ruth. Given the context provided from the various statements, it seems that Jorge and Ruth are engaged in a debate or a disagreement regarding a particular matter, potentially in a scientific or empirical research context. When we encounter phrases like "the evidence-which must ultimately decide all scientific questions" and discussions about whether there is sufficient evidence to support a hypothesis or theory, it implies a controversy or debate over the interpretation or sufficiency of evidence. Thus, the most appropriate answer to the question of what is at issue between Jorge and Ruth would be (d) Jorge and Ruth have a significant disagreement. This aligns with the notion of disputing facts, interpreting evidence, and the challenges of reaching a consensus in scientific or empirical research.