Question

An investigator is studying the adverse effects of a proteasome inhibitor, bortezomib, on immune responses. Administered to a group of patients with relapsed MM and immune response observed. Which immunologic processes are affected by the drug?

1) Activation of complement cascade
2) Activation of perforin
3) Presentation of antigens to Cd₈⁺ T lymphocytes
4) Secretion of histamine by mast cells
5) Secretion of IL-1 by macrophages

Answer 1

Bortezomib affects the activation of complement cascade and the presentation of antigens to Cd₈⁺ T lymphocytes.

Step-by-step explanation:

The immunologic processes affected by the drug bortezomib are:

1. Activation of complement cascade
2. Presentation of antigens to Cd₈⁺ T lymphocytes

The drug does not directly affect the activation of perforin, secretion of histamine by mast cells, or secretion of IL-1 by macrophages.