Final answer:
The rate of oxygen uptake in a scenario where increasing workload does not affect oxygen consumption is determined by the rate of oxygen diffusion.
Step-by-step explanation:
The factor that determines the rate of oxygen uptake in a scenario where increasing workload does not affect oxygen consumption is D) Rate of oxygen diffusion. Oxygen diffusion refers to the movement of oxygen molecules from an area of higher concentration to an area of lower concentration. Under the given scenario, the rate of oxygen uptake is solely determined by how efficiently oxygen can diffuse into the body tissues.