Question

Which predominantly female valvular disorder is thought to have an autosomal dominant inheritance pattern and is thought to be associated with connective tissue disease?

a) Aortic stenosis
b) Mitral regurgitation
c) Tricuspid atresia
d) Mitral valve prolapse

Answer 1

The female predominant valvular disorder with autosomal dominant inheritance and connective tissue association is mitral valve prolapse, often seen with conditions like Marfan syndrome.

Step-by-step explanation:

The predominantly female valvular disorder thought to have an autosomal dominant inheritance pattern and is associated with connective tissue disease is mitral valve prolapse. Marfan syndrome is an example of an autosomal dominant connective tissue disorder that can be associated with mitral valve prolapse. This contrasts with conditions such as aortic stenosis and mitral regurgitation, which are more commonly due to age-related changes or damage from rheumatic fever caused by Streptococcus pyogenes, an autoimmune response that is not inherited. Rheumatic fever is itself an autoimmune disease of the heart caused by an abnormal immune response to infection with this bacterium.