Final answer:
Uncouplers interfere with ATP synthase and prevent the production of ATP during electron transport, resulting in a decrease in the ATP/ADP ratio.
Step-by-step explanation:
Uncouplers, such as 2,4-dinitrophenol and dicumarol, interfere with ATP synthase during electron transport. While electron transport still occurs, the uncouplers prevent the production of ATP. As a result, all the energy released during electron transport is dissipated as heat instead of being used to produce ATP. This leads to a decrease in the ATP/ADP ratio.